Excipients Included in U.S. Vaccines, by Vaccine
Includes vaccine ingredients (e.g., adjuvants and preservatives) as well as substances used during the manufacturing process,
including vaccine-production media, that are removed from the final product and present only in trace quantities. In addition to the substances listed, most vaccines contain Sodium Chloride (table salt).
| Vaccine | Contains |
| Anthrax (BioThrax) | Aluminum Hydroxide, Amino Acids, Benzethonium Chloride, Formaldehyde or Formalin, Inorganic Salts, and Sugars, Vitamins |
| BCG (Tice) | Asparagine, Citric Acid, Lactose, Glycerin, Iron Ammonium Citrate, MagnesiumSulfate, Potassium Phosphate |
| DTaP (Daptacel) | Aluminum Phosphate, Ammonium Sulfate, Casamino Acid, Dimethyl-beta-cyclodextrin, Formaldehyde or Formalin, Glutaraldehyde, 2-Phenoxyethanol |
| DTaP (Infanrix) | Aluminum Hydroxide, Bovine Extract, Formaldehyde or Formalin, Glutaraldehyde, 2-Phenoxyethanol, Polysorbate 80 |
| DTaP (Tripedia) | Aluminum Potassium Sulfate, Ammonium Sulfate, Bovine Extract, Formaldehyde or Formalin, Gelatin, Polysorbate 80, Sodium Phosphate, Thimerosal* |
| DTaP/Hib (TriHIBit) | Aluminum Potassium Sulfate, Ammonium Sulfate, Bovine Extract, Formaldehyde or Formalin, Gelatin, Polysorbate 80, Sucrose, Thimerosal* |
| DTaP-IPV (Kinrix) | Aluminum Hydroxide, Bovine Extract, Formaldehyde, Lactalbumin Hydrolysate, Monkey Kidney Tissue, Neomycin Sulfate, Polymyxin B, Polysorbate 80 |
| DTaP-HepB-IPV (Pediarix) | Aluminum Hydroxide, Aluminum Phosphate, Bovine Protein, Lactalbumin Hydrolysate, Formaldehyde or Formalin, Glutaraldehyde, Monkey Kidney Tissue, Neomycin, 2-Phenoxyethanol, Polymyxin B, Polysorbate 80, Yeast Protein |
| DTaP-IPV/Hib (Pentacel) | Aluminum Phosphate, Bovine Serum Albumin, Formaldehyde, Glutaraldehyde, MRC-5 DNA and Cellular Protein, Neomycin, Polymyxin B Sulfate, Polysorbate80, 2-Phenoxyethanol, |
| DT (Sanofi) | Aluminum Potassium Sulfate, Bovine Extract, Formaldehyde or Formalin, Thimerosal (multi-dose) or Thimerosal* (single-dose) |
| DT (Massachusetts) | Aluminum Hydroxide, Formaldehyde or Formalin |
| Hib (ACTHib) | Ammonium Sulfate, Formaldehyde or Formalin, Sucrose |
| Hib (Hiberix) | Formaldehyde or Formalin, Lactose |
| Hib (PedvaxHib) | Aluminum Hydroxyphosphate Sulfate |
| Hib/Hep B (Comvax) | Amino Acids, Aluminum Hydroxyphosphate Sulfate, Dextrose, Formaldehyde or Formalin, Mineral Salts, Sodium Borate, Soy Peptone, Yeast Protein |
| Hep A (Havrix) | Aluminum Hydroxide, Amino Acids, Formaldehyde or Formalin, MRC-5Cellular Protein, Neomycin Sulfate, 2-Phenoxyethanol, Phosphate Buffers,Polysorbate |
| Hep A (Vaqta) | Aluminum Hydroxyphosphate Sulfate, Bovine Albumin or Serum, DNA, Formaldehyde or Formalin, MRC-5 Cellular Protein, Sodium Borate |
| Hep B (Engerix-B) | Aluminum Hydroxide, Phosphate Buffers, Thimerosal*, Yeast Protein |
| Vaccine | Contains |
| Hep B (Recombivax) | Aluminum Hydroxyphosphate Sulfate, Amino Acids, Dextrose, Formaldehyde or Formalin, Mineral Salts, Potassium Aluminum Sulfate, Soy Peptone, Yeast Protein |
| HepA/HepB (Twinrix) | Aluminum Hydroxide, Aluminum Phosphate, Amino Acids, Dextrose, Formaldehyde or Formalin, Inorganic Salts, MRC-5 Cellular Protein, Neomycin Sulfate, 2-Phenoxyethanol, Phosphate Buffers, Polysorbate 20, Thimerosal*, Vitamins, Yeast Protein |
| Human Papillomavirus (HPV)Cervarix) | 3-O-desacyl-4’-monophosphoryl lipid A (MPL), Aluminum Hydroxide, Amino Acids, Insect Cell Protein, Mineral Salts, Sodium Dihydrogen Phosphate Dihydrate, Vitamins |
| Human Papillomavirus (HPV) (Gardasil) | Amino Acids, Amorphous Aluminum Hydroxyphosphate Sulfate, Carbohydrates, L-histidine, Mineral Salts, Polysorbate 80, Sodium Borate, Vitamins |
| Influenza (Afluria) | Beta-Propiolactone, Calcium Chloride, Neomycin, Ovalbumin, Polymyxin B, Potassium Chloride, Potassium Phosphate, Sodium Phosphate, Sodium Taurodeoxychoalate |
| Influenza (Agriflu) | Cetyltrimethylammonium Bromide (CTAB), Egg Protein, Formaldehyde orFormalin, Kanamycin, Neomycin Sulfate, Polysorbate 80 |
| Influenza (Fluarix) | Egg Albumin (Ovalbumin), Egg Protein, Formaldehyde or Formalin, Gentamicin, Hydrocortisone, Octoxynol-10, α-Tocopheryl Hydrogen Succinate, Polysorbate 80, Sodium Deoxycholate, Sodium Phosphate, Thimerosal* |
| Influenza (Flulaval) | Egg Albumin (Ovalbumin), Egg Protein, Formaldehyde or Formalin, SodiumDeoxycholate, Phosphate Buffers, Thimerosal |
| Influenza (Fluvirin) | Beta-Propiolactone , Egg Protein, Neomycin, Polymyxin B, Polyoxyethylene9-10 Nonyl Phenol (Triton N-101, Octoxynol 9), Thimerosal (multidose containers), Thimerosal* (single-dose syringes) |
| Influenza (Fluzone) | Egg Protein, Formaldehyde or Formalin, Gelatin, Octoxinol-9 (Triton X-100), Thimerosal (multidose containers) |
| Influenza (FluMist) | Chick Kidney Cells, Egg Protein, Gentamicin Sulfate, Monosodium Glutamate, Sucrose Phosphate Glutamate Buffer |
| IPV (Ipol) | Calf Serum Protein, Formaldehyde or Formalin, Monkey Kidney Tissue, Neomycin, 2-Phenoxyethanol, Polymyxin B, Streptomycin, |
| Japanese Encephalitis(JE-Vax) | Formaldehyde or Formalin, Gelatin, Mouse Serum Protein, Polysorbate 80, Thimerosal |
| Japanese Encephalitis (Ixiaro) | Aluminum Hydroxide, Bovine Serum Albumin, Formaldehyde, ProtamineSulfate, Sodium Metabisulphite |
| Meningococcal (Menactra) | Formaldehyde or Formalin, Phosphate Buffers |
| Meningococcal (Menomune) | Lactose, Thimerosal (10-dose vials only) |
| Meningococcal (Menveo) | Amino Acid, Formaldehyde or Formalin, Yeast |
| MMR (MMR-II) | Amino Acid, Bovine Albumin or Serum, Chick Embryo Fibroblasts, Human Serum Albumin, Gelatin, Glutamate, Neomycin, Phosphate Buffers, Sorbitol, Sucrose, Vitamins |
| Vaccine | Contains |
| MMRV (ProQuad) | Bovine Albumin or Serum, Gelatin, Human Serum Albumin, MonosodiumL-glutamate, MRC-5 Cellular Protein, Neomycin, Sodium Phosphate Dibasic, Sodium Bicarbonate, Sorbitol, Sucrose, Potassium Phosphate Monobasic, Potassium Chloride, Potassium Phosphate Dibasic |
| Pneumococcal (Pneumovax) | Bovine Protein, Phenol |
| Pneumococcal (Prevnar) | Aluminum Phosphate, Amino Acid, Soy Peptone, Yeast Extract |
| Pneumococcal (Prevnar 13) | Aluminum Phosphate, Amino Acid, Polysorbate 80, Soy Peptone, Succinate Buffer, Yeast Extract |
| Rabies (Imovax) | Human Serum Albumin, Beta-Propiolactone, MRC-5 Cellular Protein, Neomycin, Phenol Red (Phenolsulfonphthalein), Vitamins |
| Rabies (RabAvert) | Amphotericin B, Beta-Propiolactone, Bovine Albumin or Serum, ChickenProtein, Chlortetracycline, Egg Albumin (Ovalbumin), Ethylenediamine-Tetraacetic Acid Sodium (EDTA), Neomycin, Potassium Glutamate |
| Rotavirus (RotaTeq) | Cell Culture Media, Fetal Bovine Serum, Sodium Citrate, Sodium PhosphateMonobasic Monohydrate, Sodium Hydroxide Sucrose, Polysorbate 80 |
| Rotavirus (Rotarix) | Amino Acids, Calcium Carbonate, Calcium Chloride, D-glucose, Dextran, Ferric (III) Nitrate, L-cystine, L-tyrosine, Magnesium Sulfate, Phenol Red, Potassium Chloride, Sodium Hydrogenocarbonate, Sodium Phosphate, SodiumL-glutamine, Sodium Pyruvate, Sorbitol, Sucrose, Vitamins, Xanthan |
| Td (Decavac) | Aluminum Potassium Sulfate, Bovine Extract, Formaldehyde or Formalin, 2-Phenoxyethanol, Peptone, Thimerosal* |
| Td (Massachusetts) | Aluminum Hydroxide, Aluminum Phosphate, Formaldehyde or Formalin, Thimerosal (some multidose containers) |
| Tdap (Adacel) | Aluminum Phosphate, Formaldehyde or Formalin, Glutaraldehyde, 2-Phenoxyethanol |
| Tdap (Boostrix) | Aluminum Hydroxide, Bovine Extract, Formaldehyde or Formalin, Glutaraldehyde, Polysorbate 80 |
| Typhoid (inactivated – TyphimVi) | Disodium Phosphate, Monosodium Phosphate, Phenol, Polydimethylsilozone, Hexadecyltrimethylammonium Bromide |
| Typhoid (oral – Ty21a) | Amino Acids, Ascorbic Acid, Bovine Protein, Casein, Dextrose, Galactose, Gelatin, Lactose, Magnesium Stearate, Sucrose, Yeast Extract |
| Vaccinia (ACAM2000) | Glycerin, Human Serum Albumin, Mannitol, Monkey Kidney Cells, Neomycin, Phenol, Polymyxin B |
| Varicella (Varivax) | Bovine Albumin or Serum, Ethylenediamine-Tetraacetic Acid Sodium (EDTA), Gelatin, Monosodium L-Glutamate, MRC-5 DNA and Cellular Protein,Neomycin, Potassium Chloride, Potassium Phosphate Monobasic, Sodium Phosphate Monobasic, Sucrose |
| Yellow Fever (YF-Vax) | Egg Protein, Gelatin, Sorbitol |
| Zoster (Zostavax) | Bovine Calf Serum, Hydrolyzed Porcine Gelatin, Monosodium L-glutamate, MRC 5 DNA and Cellular Protein, Neomycin, Potassium Phosphate Monobasic, Potassium Chloride, Sodium Phosphate Dibasic, Sucrose |
*Where “thimerosal” is marked with an asterisk (*) it indicates that the product should be considered equivalent to thimerosal-free products. This vaccine may contain trace amounts (3 mcg) of mercury left after post-production thimerosal removal, but these amounts have no biological effect. JAMA 1999;282(18) and JAMA 2000;283(16)
Adapted from Grabenstein JD. ImmunoFacts: Vaccines & Immunologic Drugs. St. Louis, MO: Wolters Kluwer
Health Inc.; 2009 and individual products’ package inserts.
All reasonable efforts have been made to ensure the accuracy of this information, but manufacturers may change product contents before that information is reflected here.
This document can be found on the CDC website at:
http://www.cdc.gov/vaccines/pubs/pinkbook/downloads/appendices/B/excipient-table-2.pdf
To obtain more information on vaccination safety and to schedule your appointment please call our office at (800)669-0358 and discover preventive and intervention methods to health and healing